21 randomised clinical trials with 13 823 participants were included in the meta-analysis. RAS inhibitors were associated with reduced risk of progression (absolute risk difference −3%, 95% CI −5 to −1; pooled RR 0·87, 95% CI 0·80–0·95; p=0·002) and increased possibility of regression of diabetic retinopathy (8%, 1–16; RR 1·39, 95% CI 1·19–1·61; p=0·00002). Nov 13, 2020 · SAN FRANCISCO, Nov. 13, 2020 (GLOBE NEWSWIRE) -- BridgeBio Pharma, Inc. (Nasdaq: BBIO) and affiliate Navire Pharma, Inc. announced today that the first patient has been dosed in a Phase 1 clinical trial of its SHP2 inhibitor (BBP-398) in patients with solid tumors driven by mutations in the MAPK signaling pathway, including RAS and receptor tyrosine kinase genes.
Nov 16, 2019 · Multiple KRAS G12C inhibitors are in development, and the identification of effective combination treatment regimens should maximize the benefit these agents have on cancer patients. Here, we find that KRAS G12C heterozygous mutated colorectal cancer cells are sensitive to targeting with EGFR therapeutic antibodies. We find that KRAS G12C is partially impaired in binding to tumor suppressor ... BridgeBio Pharma, Inc. (NASDAQ: BBIO) and affiliate Navire Pharma, Inc. announced today that the first patient has been dosed in a Phase 1 clinical trial of its SHP2 inhibitor (BBP-398) in ...
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